Tianeptine & The Opioid-Addicted Brain

An old medication I’ve researched the hell out of, that seems REALLY valuable somehow, even if it wasn’t quite explainable in its mechanisms (and really unavailable in AU now), has involvement in the opioid system in the brain… The same area of the brain that I found my research was pointing to (with big neon flashing arrows, too) as the real centre of mood, motivation and basically human behaviour rather than serotonin/dopamine/norepinephrine as has been claimed – and an area that they’ve found is one of the most intensely protected by the blood-brain barrier (no wonder if it’s mission control, I think)… Not just that, but IT CAN TALK TO MU! It can talk to ALL of the opioid receptors! Holy moley…
” A breakthrough in tianeptine research was announced in July 2014 with the unexpected discovery that tianeptine is a full agonist at the mu and delta opioid receptors with negligible effect at the kappa opioid receptors. Selective mu opioid agonists in the brain’s “hedonic hotspots” typically induce euphoria. Selective kappa agonists typically induce dysphoria. The role of central delta opioid receptors is poorly understood. Dual activation of the mu and, less potently, delta opioid receptors may be critical to tianeptine’s mood-brightening and anxiolytic effect – a therapeutic action seemingly unaccompanied by the physiological tolerance and dependence that have plagued traditional opioids. All previous research into tianeptine may need to be re-evaluated in this light. More research is urgently needed.”
I can’t get over how many signs are beginning to solidify what I saw… And repeat themselves in the places I saw non-existent connections!! The idea of actually getting anything right on my own, informally, is actually something I find almost impossible to believe I’ll ever succeed at.
If my guess is right, I’m going to the ceremony where someone with more discipline than me gets the Nobel prize I wanted to win with this hypothesis. They deserve it!


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